Mangalore Refinery granted US patent for method of preparation of iso-Butyl Benzene

31 May 2025 Evaluate

Mangalore Refinery and Petrochemicals (MRPL) has been granted a US patent for the method of preparation of iso-Butyl Benzene (i-BB), recognizing the novelty and technical excellence of the in-house developed process. This marks a major step forward in establishing MRPL's global footprint in pharmaceutical technology innovation, complementing the previously granted Indian patent. Through this, MRPL achieved a significant breakthrough in pharmaceutical ingredient synthesis by successfully developing an innovative technology for i-BB production. 

This pioneering process involves the side-chain alkylation of an aromatic moiety from a low-value captive stream, facilitated by a newly engineered catalyst developed at MRPL's Innovation Centre. The catalyst is meticulously designed for high conversion rates and outstanding selectivity towards the desired i-BB product. Iso-Butyl Benzene is a critical intermediate in the synthesis of Brufen, a widely used analgesic drug. By developing this technology indigenously, MRPL reduces dependence on imported materials and strengthens its contribution to the domestic pharmaceutical sector. This advancement underscores MRPL's ongoing commitment to research, innovation, and the development of cutting-edge technologies, enhancing India's pharmaceutical manufacturing capabilities. Currently, MRPL is setting up a pilot plant for i-BB production, a key step towards commercial-scale production.

Mangalore Refinery and Petrochemicals is Category 1 Miniratna Central Public Sector Enterprise (CPSE) under the Ministry of Petroleum & Natural Gas. The company is engaged in the business of refining of crude oil. 


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